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Product Name
Anti-S100A5 antibody
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Description
Rabbit monoclonal to S100A5
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Tested applications
IHC-P
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Species reactivity
Mouse S100A5
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Alternative names
S100A5 antibody; S100A5 antibody; S100D antibody; S100D9 antibody; S100D antibody; S100D9 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse S100A5 (rM S100A5; P63084; Met1-Lys93).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.01-2 μg/mL
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Validations
S100A5 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of mouse S100A5 in mouse brain with rabbit monoclonal antibody (0.01 µg/mL, formalin-fixed paraffin embedded sections).
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Background
S100 protein?is a family of low molecular weight protein found in vertebrates characterized by two?EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is?100%?soluble in ammonium sulfate?at neutral?pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the?neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.?? Protein S100-A5, also known as Protein S-100D, S100 calcium-binding protein A5, S100A5 and S100D, is a member of the S100 family which contains two?EF-hand domains. S100A5 is also a novel member of the EF-hand superfamily of calcium-binding proteins that is poorly characterized at the protein level. It is expressed in very restricted regions of the adult brain. From birth onwards, S100A5 remained a neuronal-specific protein, only located in a subpopulation of neurons in the spiral ganglion.
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References
- Sch?fer,B.W. et al., 2000, J Biol Chem. 275 (39):30623-30.
- Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31.
- Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9.
- Lim, SY. et al., 2008, J Immunol. 181 (8): 5627-36.
- Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"