Anti-RSPO1 antibody

Anti-RSPO1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse RSPO1

ELISA, IHC-P

Mouse R-Spondin 1 / RSPO1

R-Spondin 1 antibody; CRISTIN3 antibody; FLJ40906 antibody; RP11-566C13.1 antibody; RP23-325M14.2 antibody; RSPO antibody; Rspo1 antibody; RSPO1 antibody; Rspondin antibody; R-spondin antibody; R-spondin1 antibody; Rspondin antibody; R-spondin antibody; RSPO antibody; CRISTIN3 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse R-Spondin 1 / RSPO1 . R-Spondin 1 / RSPO1 specific IgG was purified by Mouse R-Spondin 1 / RSPO1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.