Anti-RBBP4/RBAP48 antibody

Anti-RBBP4/RBAP48 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to RBBP4/RBAP48

WB, IHC-P, IF, ICC/IF

Human RBBP4 / RBAP48

CAF-1 subunit C antibody; CAF-1 subunit C antibody; CAF-I 48 kDa subunit antibody; CAF-I 48 kDa subunit antibody; CAF-I p48 antibody; CAF-I p48 antibody; mRbAp48 antibody; NURF55 antibody; RBAP48 antibody; RBBP4 antibody; Rbbp4 antibody; RBBP-4 antibody; RBBP-4 antibody; RP23-391E6.3 antibody; CAF-1 p48 subunit antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human RBBP4 / RBAP48, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling factor subunit RBAP48 and RBBP4, is a nucleus protein which belongs to the WD repeat RBAP46/RBAP48/MSI1 family. RBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling and the NURF (nucleosome remodeling factor) complex.One common myth is that age-related memory loss is an early indication of Alzheimer's disease. But researchers at the Columbia University Medical Center in New York City have found a specific protein, RbAp48, that they believe is responsible for age-related memory problems. What's more, by replenishing RbAp48 in the brains of mice, the researchers were able to undo existing age-related memory damage.To find RbAp48, researchers focused on the hippocampus, the region of the brain where memories are formed. After studying eight healthy brains donated to science by people between the ages of 33 and 88, they found that RbAp48 was reduced by nearly 50 percent in the older brains. The researchers found that when they turned off RbAp48 in younger mice, they became more forgetful, while increasing RbAp48 in older mice restored memory. The mice were given memory tests that included object recognition and water maze problems.

• Rasmussen HH. et al.,1992, Electrophoresis 13:960-9.
• Qian Y.-W. et al., 1993,  Nature 364:648-52.
• Yarden R.I. et al., 1999, Proc. Natl. Acad. Sci. USA. 96: 4983-8.
• Ota T. et al., 2004, Nat. Genet. 36:40-45.
• Gauci S. et al., 2009, Anal. Chem. 81:4493-501.