Anti-QPCT antibody

Anti-QPCT antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human QPCT

ELISA, IHC-P

Human Glutaminyl cyclase / QPCT

QC antibody; GCT antibody; sQC antibody; 5730422A13Rik antibody; 5730422A13Rik antibody; EC antibody; GCT antibody; glutaminyl cyclase antibody; glutaminyl cyclase antibody; glutaminyl-peptide cyclotransferase antibody; glutaminyl-peptide cyclotransferase antibody; glutaminyl-peptide cyclotransferase (glutaminyl cyclase) antibody; glutaminyl-tRNA cyclotransferase antibody; glutaminyl-tRNA cyclotransferase antibody; glutamyl cyclase antibody; QC antibody; QC antibody; Qpct antibody; QPCT antibody; sQC antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Glutaminyl cyclase / QPCT . Glutaminyl cyclase / QPCT specific IgG was purified by Human Glutaminyl cyclase / QPCT affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.