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Product Name
Anti-PSMC5 Rabbit antibody
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Description
PSMC5 Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human PSMC5
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/2000-1/10000
ICC/IF: 1/50
FC: 1/20-1/100
IP: 1/20
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Validations
Western blot detection of PSMC5 in C6,Hela cell lysates using PSMC5 Rabbit mAb(1:1000 diluted).Predicted band size:46kDa.Observed band size:46kDa.
Immunocytochemistry of PSMC5(green) in Hela cells using PSMC5 Rabbit mAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.P62195.Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"