Anti-PS6K / RPS6KB1 antibody

Anti-PS6K / RPS6KB1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to PS6K / RPS6KB1

WB, IF, IP

Human PS6K / RPS6KB1

2610318I15Rik antibody; 4732464A07Rik antibody; 70 kDa ribosomal protein S6 kinase 1 antibody; 70 kDa ribosomal protein S6 kinase 1 antibody; 70kD antibody; AA959758 antibody; AI256796 antibody; AI314060 antibody; alpha 2 antibody; p70 ribosomal S6 kinase alpha antibody; p70 S6 kinase antibody; p70 S6 kinase alpha antibody; p70 S6KA antibody; p70 S6KA antibody; p70 S6K-alpha antibody; p70 S6K-alpha antibody; p70(S6K)-alpha antibody; p70/85s6k antibody; alpha 1 antibody; p70-alpha antibody; p70s6k antibody; p70-S6K antibody; p70-S6K 1 antibody; P70S6K1 antibody; P70S6K1 antibody; polypeptide 1 antibody; PS6K antibody; ribosomal protein S6 kinase antibody; ribosomal protein S6 kinase beta-1 antibody; ribosomal protein S6 kinase beta-1 antibody; ribosomal protein S6 kinase I antibody; ribosomal protein S6 kinase I antibody; RP23-467J12.2 antibody; S6K antibody; S6K antibody; S6K1 antibody; S6K1 antibody; S6K-beta-1 antibody; S6K-beta-1 antibody; serine/threonine kinase 14 alpha antibody; serine/threonine-protein kinase 14A antibody; STK14A antibody; 70kDa antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human PS6K / RPS6KB1 (rh PS6K / RPS6KB1; P23443; Met1-Leu525). PS6K / RPS6KB1 specific IgG was purified by Human PS6K / RPS6KB1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.

• Panasyuk, et al. (2006) Nuclear export of PS6K II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem. 281(42):31188-201.
• Carnevalli L, et al. (2010) PS6K Plays a Critical Role in Early Adipocyte Differentiation. Dev Cell. 18 (5):763-74.
• Grove JR, et al. (1991) Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol. 11(11):5541-50.