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Product Name
Anti-Prostaglandin D Synthase Rabbit antibody
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Description
Prostaglandin D Synthase Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Prostaglandin D Synthase
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/20
ICC/IF: 1/20
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Validations
Western blot detection of Prostaglandin D Synthase in K562,C6,3T3,Hela cell lysates using Prostaglandin D Synthase Rabbit pAb(1:1000 diluted).Predicted band size:21kDa.Observed band size:26kDa.
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Background
Swiss-Prot Acc.P41222.Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"