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  • Anti-Prohibitin (5H7) Mouse antibody

Anti-Prohibitin (5H7) Mouse antibody

Cat.#: 168363

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Product Information

  • Product Name
    Anti-Prohibitin (5H7) Mouse antibody
  • Documents
  • Description
    Prohibitin (5H7) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human, Mouse, Rat, Monkey
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant fragment of human PHB expressed in E. Coli.
  • Clonality
    Monoclonal antibody
  • Formulation
    Ascitic fluid containing 0.03% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ICC: 1/200 - 1/1000

    FC: 1/200 - 1/400

    ELISA: 1/10000

  • Validations

    Western blot detection of Prohibitin in C6,COS7,3T3 and Hela cell lysates using Prohibitin mouse mAb (dilution 1:1000).Predicted band size:30 Kda.Observed band size:30KDa.

    Western blot detection of Prohibitin in C6,COS7,3T3 and Hela cell lysates using Prohibitin mouse mAb (dilution 1:1000).Predicted band size:30 Kda.Observed band size:30KDa.

  • Background
    Swiss-Prot Acc.P35232.Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"