-
Product Name
Anti-PRC1 Rabbit antibody
- Documents
-
Description
PRC1 Rabbit monoclonal antibody
-
Tested applications
WB, IHC-P, ICC/IF, FC, IP
-
Species reactivity
Human, Mouse, Rat
-
Alternative names
ASE1 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: A synthetic peptide of human PRC1
-
Clonality
Monoclonal
-
Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
Applications
WB: 1/2000
IHC: 1/20
ICC/IF: 1/20
FC: 1/20
IP: 1/20
-
Validations
Western blot detection of PRC1 in C6,Jurkat cell lysates using PRC1 Rabbit mAb(1:500 diluted).Predicted band size:72kDa.Observed band size:72kDa.
-
Background
Swiss-Prot Acc.O43663.Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"