Anti-PRC1 Rabbit antibody

Cat.#: 168941

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Product Information

  • Product Name
    Anti-PRC1 Rabbit antibody
  • Documents
  • Description
    PRC1 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    ASE1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human PRC1
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/2000

    IHC: 1/20

    ICC/IF: 1/20

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of PRC1 in C6,Jurkat cell lysates using PRC1 Rabbit mAb(1:500 diluted).Predicted band size:72kDa.Observed band size:72kDa.

    Western blot detection of PRC1 in C6,Jurkat cell lysates using PRC1 Rabbit mAb(1:500 diluted).Predicted band size:72kDa.Observed band size:72kDa.

  • Background
    Swiss-Prot Acc.O43663.Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"