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Product Name
Anti-PPC-DC / PPCDC antibody
- Documents
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Description
Rabbit polyclonal to PPC-DC / PPCDC
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Tested applications
ELISA, IHC-P
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Species reactivity
Human PPC-DC / PPCDC
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Alternative names
coaC antibody; MDS018 antibody; PPC-DC antibody; 1810057I13Rik antibody; 8430432M10Rik antibody; phosphopantothenoylcysteine decarboxylase antibody; PPCDC antibody; MDS018 antibody; PPC-DC antibody; coaC antibody; phosphopantothenoylcysteine decarboxylase antibody; Ppcdc antibody; 1810057I13Rik antibody; 8430432M10Rik antibody; PPC-DC antibody; coaC antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human PPC-DC / PPCDC (rh PPC-DC / PPCDC; AAH14409.1; Met1-Ser204). PPC-DC / PPCDC specific IgG was purified by Human PPC-DC / PPCDC affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human PPC-DC / PPCDC. The detection limit for Human PPC-DC / PPCDC is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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Validations
PPC-DC / PPCDC Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
PPC-DC, also known as PPCDC, belongs to the HFCD (homo oligomeric flavin containing Cys decarboxylase) superfamily which takes a part in the biosynthesis of coenzyme A (CoA) from pantothenate (Vitamin B). Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. This process include several steps: the phosphorylation of pantothenate, the conversion of 4’-hosphopantothenate to 4''-phosphopantetheine, the adenylation by phosphopantetheine adenylyltransferase to form dephospho-CoA and the phosphorylation by dephospho-CoA kinase to form CoA. PPC-DC, one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine.
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References
- Zody MC. et al., 2006, Nature. 440: 671-5.
- Ota T. et al., 2004, Nat Genet. 36: 40-5.
- Clark HF. et al., 2003, Genome Res. 13: 2265-70.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"