Cart 2
  • Anti-phospho-PML Protein (Ser518) Rabbit antibody

Anti-phospho-PML Protein (Ser518) Rabbit antibody

Cat.#: 167924

Size:

Special Price 247.7 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-phospho-PML Protein (Ser518) Rabbit antibody
  • Documents
  • Description
    phospho-PML Protein (Ser518) Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Mouse
  • Isotype
    IgG
  • Preparation
    Antigen: A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/50

  • Validations

    Western blot detection of phospho-PML Protein (Ser518) in A549,HL-60,U2OS cell lysates using phospho-PML Protein (Ser518) Rabbit mAb(1:1000 diluted).Predicted band size:98kDa.Observed band size:98-117kDa.

    Western blot detection of phospho-PML Protein (Ser518) in A549,HL-60,U2OS cell lysates using phospho-PML Protein (Ser518) Rabbit mAb(1:1000 diluted).Predicted band size:98kDa.Observed band size:98-117kDa.

  • Background
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"