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Product Name
Anti-phospho-MEK4/MKK4 (Ser80) Rabbit antibody
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Description
phospho-MEK4/MKK4 (Ser80) Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, IP
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Species reactivity
Human, Mouse
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Isotype
IgG
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Preparation
Antigen: A synthetic phosphopeptide corresponding to residues surrounding Ser80 of human MEK4/MKK4
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/2000
IHC: 1/20
IP: 1/20
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Validations
Western blot detection of phospho-MEK4/MKK4 (Ser80) in A549,MCF-7,U251 cell lysates using phospho-MEK4/MKK4 (Ser80) Rabbit mAb(1:1000 diluted).Predicted band size:44kDa.Observed band size:44kDa.
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Background
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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