Anti-phospho-Amyloid Precursor Protein (Thr743) Rabbit antibody

Cat.#: 167767

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Product Information

  • Product Name
    Anti-phospho-Amyloid Precursor Protein (Thr743) Rabbit antibody
  • Documents
  • Description
    phospho-Amyloid Precursor Protein (Thr743) Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, IP
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    ICC/IF: 1/20

    IP: 1/20

  • Validations

    Western blot detection of phospho-Amyloid Precursor Protein (Thr743)  in Hela,U2OS,C6 cell lysates using phospho-Amyloid Precursor Protein (Thr743)  Rabbit mAb(1:1000 diluted).Predicted band size:87kDa.Observed band size:100kDa.

    Western blot detection of phospho-Amyloid Precursor Protein (Thr743) in Hela,U2OS,C6 cell lysates using phospho-Amyloid Precursor Protein (Thr743) Rabbit mAb(1:1000 diluted).Predicted band size:87kDa.Observed band size:100kDa.

  • Background
    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"