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Product Name
Anti-Periostin antibody
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Description
Rabbit polyclonal to Periostin
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Tested applications
ELISA, IHC-P
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Species reactivity
Mouse Periostin / POSTN
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Alternative names
PN antibody; OSF2 antibody; OSF-2 antibody; PDLPOSTN antibody; periostin antibody; PN antibody; PLF antibody; Osf2 antibody; peri antibody; OSF-2 antibody; AI747096 antibody; A630052E07Rik antibody; AI747096 antibody; MGC119510 antibody; MGC119511 antibody; Osf2 antibody; OSF2 antibody; OSF-2 antibody; OSF-2 antibody; PDLPOSTN antibody; peri antibody; Periostin antibody; Periostin antibody; PLF antibody; PN antibody; PN antibody; Postn antibody; POSTN antibody; RP11-412K4.1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse Periostin / POSTN (rM Periostin / POSTN; NP_056599.1; Met 1-Gln 811). Periostin / POSTN specific IgG was purified by Mouse Periostin / POSTN affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse POSTN. The detection limit for Mouse POSTN is less than 0.039 ng/well.
IHC-P: 0.1-2 μg/mL
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Validations
Periostin / POSTN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of mouse POSTN in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.
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References
- Kudo,Y. et al., 2007, Histol Histopathol. 22 (10):1167-1174.
- Li, J.S. et al., 2007, World J Gastroenterol. 13 (39): 5261-5266.
- Oku, E. et al., 2008, Int J Hematol. 88 (1): 57-63.
- Hamilton, D.W. et al., 2008, J Cell Commun Signal. 2(1-2):9-17.
- Puglisi, F.J et al., 2008, Clin Pathol. 61 (4): 494-498.
- Conway, S. J. et al., 2008, Curr Genomics. 9 (8): 548-555.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"