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Product Name
Anti-PEDF antibody
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Description
Rabbit monoclonal to PEDF
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Tested applications
WB
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Species reactivity
Human SerpinF1 / PEDF
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Alternative names
OI6 antibody; AI195227 antibody; EPC-1 antibody; EPC-1 antibody; PEDF antibody; Pedf antibody; Pedfl antibody; PIG35 antibody; RP23-384C18.1 antibody; Sdf3 antibody; SERPINF1 antibody; Serpinf1 antibody; OI12 antibody; PEDF antibody; EPC-1 antibody; PIG35 antibody; Pedf antibody; Sdf3 antibody; EPC-1 antibody; Pedfl antibody; AI195227 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinF1 / PEDF (rh SerpinF1 / PEDF; NP_002606.3; Met1-Pro418).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS with 5% treha
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 20-30 μg/ml
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Validations
SerpinF1 / PEDF Antibody, Rabbit MAb, Western blot
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Background
Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
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References
- Ren, JG. et al., 2005, Med Hypotheses. 64 (1): 74-8.
- Filleur, S. et al., 2009. J Cell Biochem. 106 (5): 769-75.
- Kawaguchi, T. et al., 2010, Curr Mol Med. 10 (3): 302-11.
- Yamagishi, SI. et al., 2010, Curr Mol Med. 10 (3): 284-91.
- Nakamura, T. et al., 2010, Curr Mol Med. 10 (3): 312-6.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"