Anti-PCNA (9C9) Mouse antibody

Anti-PCNA (9C9) Mouse antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PCNA (9C9) Mouse monoclonal antibody

WB, ICC/IF, IHC-P

Human, Rat, Mouse

Mouse IgG1

Antigen: Synthetic Peptide of PCNA

Monoclonal

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P12004.Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.