Anti-PABPN1 Rabbit antibody

Anti-PABPN1 Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PABPN1 Rabbit polyclonal antibody

WB, IHC-P, ICC/IF, FC, IP

Human, Mouse

OPMD; PAB2; PABII; PABP2; PABP-2 antibody

Rabbit IgG

Antigen: A synthetic peptide of human PABPN1

Polyclonal

Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.

Swiss-Prot Acc.Q86U42.Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product . Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length . Increases the affinity of poly(A) polymerase for RNA . Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity . May protect the poly(A) tail from degradation . Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).