Anti-ORP150/HYOU1/HSP12A (Grp170) antibody

Anti-ORP150/HYOU1/HSP12A (Grp170) antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to ORP150/HYOU1/HSP12A (Grp170)

ELISA, IHC-P

Human HYOU1 / HSP12A

Grp170 antibody; Grp170 antibody; GRP-170 antibody; GRP-170 antibody; HSP12A antibody; Hyou1 antibody; Orp150 antibody; ORP150 antibody; AI415631 antibody; Cab140 antibody; HYOU1 antibody; ORP-150 antibody; Cab140 antibody; Grp170 antibody; Orp150 antibody; CBP-140 antibody; AI415631 antibody; Grp170 antibody; HSP12A antibody; ORP150 antibody; GRP-170 antibody; ORP-150 antibody; CBP-140 antibody; DKFZp686N08236 antibody; FLJ94899 antibody; FLJ97572 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human HSP12A (rh HSP12A; NP_001124463.1; Met 695-Leu 994). HSP12A specific IgG was purified by human HSP12A affinity chromatography

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hypoxia up-regulated protein 1, also known as 150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, ORP-150, GRP-170 and HYOU1, is a member of the heat shock protein 70 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP150), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP60), and several isoforms of the two testis-specific HSP70 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. It is highly expressed in liver and pancreas. HYOU1 is also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. HYOU1 has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. It may play a role as a molecular chaperone and participate in protein folding. Suppression of HYOU1 is associated with accelerated apoptosis. It is suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness.