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Product Name
Anti-Olig-2 antibody
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Description
Rabbit polyclonal to Olig-2
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Tested applications
WB, IHC-P
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Species reactivity
Human Olig-2 / Oligo2
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, a synthetic peptide corresponding to the N-terminus of the Human Olig-2 / Oligo2, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 1-2 μg/mL
IHC-P: 0.1-2 μg/mL
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Validations
Olig-2 / Oligo2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Olig-2 / Oligo2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of human olig-2 in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia.
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References
- Wang J, et al., 2000, Proc Natl Acad Sci. 97(7): 3497-502.
- Lu QR, et al., 2001, Proc Natl Acad Sci. 98(19): 10851-6.
- Marie Y, et al., 2001, Lancet. 358(9278): 298-300.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"