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Product Name
Anti-NUMB Rabbit antibody
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Description
NUMB Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
S171; C14orf41; c14_5527 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human NUMB
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/200
FC: 1/100
IP: 1/20
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Validations
Western blot detection of NUMB in 3T3,C6,Rat Brain,MCF7 cell lysates using NUMB Rabbit pAb(1:1000 diluted).Predicted band size:71kDa.Observed band size:71kDa.
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Background
Swiss-Prot Acc.P49757.Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"