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Product Name
Anti-Nuf2 Rabbit antibody
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Description
Nuf2 Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC
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Species reactivity
Human
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Alternative names
CDCA1; CT106; NUF2R antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Nuf2
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
ICC/IF: 1/100
FC: 1/20
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Validations
Western blot detection of Nuf2 in K562 cell lysates using Nuf2 Rabbit pAb(1:1000 diluted).Predicted band size:54kDa.Observed band size:54kDa.
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Background
Swiss-Prot Acc.Q9BZD4.Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"