-
Product Name
Anti-NRG1 antibody
- Documents
-
Description
Mouse monoclonal to NRG1
-
Tested applications
WB
-
Species reactivity
Human NRG1-beta 1
No cross-reactivity in WB with Human NRG1-alpha -
Alternative names
HGL antibody; HGL antibody; 6030402G23Rik antibody; ARIA antibody; ARIA antibody; D230005F13Rik antibody; GGF antibody; GGF antibody; GGF2 antibody; GGFII antibody; Hgl antibody; HRG antibody; HRG antibody; HRG1 antibody; HRGA antibody; HRGalpha antibody; MST131 antibody; NDF antibody; NDF antibody; SMDF antibody; SMDF antibody; GGF antibody; HRG antibody; NDF antibody; ARIA antibody; GGF2 antibody; HRG1 antibody; HRGA antibody; SMDF antibody; MST131 antibody; MSTP131 antibody; NRG1-IT2 antibody; GGF antibody; HRG antibody; Hgl antibody; NDF antibody; ARIA antibody; SMDF antibody; GGFII antibody; HRGalpha antibody; 6030402G23Rik antibody; D230005F13Rik antibody
-
Isotype
Mouse IgG2b
-
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
-
Clonality
Monoclonal
-
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 1-2 μg/mL
-
Validations
NRG1-beta 1 Antibody, Mouse MAb, Western blot
-
Background
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
-
References
- Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
- Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
- Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"