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Product Name
Anti-Neurexophilin-1/NXPH1 antibody
- Documents
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Description
Rabbit monoclonal to Neurexophilin-1/NXPH1
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Tested applications
IHC-P
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Species reactivity
Rat Neurexophilin-1 / NXPH1
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Alternative names
NPH1 antibody; Nbla00697 antibody; C130005L03Rik antibody; NXPH1 antibody; NXPH1 antibody; C130005L03Rik antibody; Nbla00697 antibody; Neurexophilin-1 antibody; Neurexophilin-1 antibody; NPH1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat Neurexophilin-1 / NXPH1 (rR Neurexophilin-1 / NXPH1; Q63366-1; Met1-Gly271).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.05-2 μg/mL
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Validations
Neurexophilin-1 / NXPH1 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of rat NXPH1 in rat brain with rabbit monoclonal antibody (0.05 µg/mL, formalin-fixed paraffin embedded sections).
Neurexophilin-1 / NXPH1 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of rat NXPH1 in rat spinal cord with rabbit monoclonal antibody (0.05 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Neurexophilin-1, or NXPH1 is a secreted glycoprotein, which belongs to the Neurexophilin family. The Neurexophilin family contain at least four genes and resembles a neuropeptide, suggesting a function as an endogenous ligand for alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Neurexophilin-1 constitutes a secreted cysteine-rich glycoprotein, forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins.
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References
- Missler M, et al. (1998) Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 273(52): 34716-23.
- Missler M, et al. (1998) Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci. 18(10): 3630-8.
- Petrenko AG, et al. (1996) Structure and evolution of neurexophilin. J Neurosci. 16(14): 4360-9.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"