-
Product Name
Anti-Nesprin3 Rabbit antibody
- Documents
-
Description
Nesprin3 Rabbit monoclonal antibody
-
Tested applications
WB
-
Species reactivity
Human
-
Alternative names
KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: Recombinant protein of human Nesprin3
-
Clonality
Monoclonal
-
Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
-
Applications
1:1000-1:2000
-
Validations
Western blot detection of Nesprin3 in Jurkat,Hela cell lysates using Nesprin3 Rabbit mAb(1:1000 diluted).Predicted band size:112kDa.Observed band size:112kDa.
-
Background
Swiss-Prot Acc.Q6ZMZ3.As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"