Mouse Monoclonal to Human MUC1
Human MUC1/Mucin 1/CD227
Muc-1 antibody; MCD antibody; MCKD antibody; EMA antibody; MCKD1 antibody; MCD antibody; PEM antibody; PUM antibody; KL-6 antibody; MAM6 antibody; MCKD antibody; PEMT antibody; CD227 antibody; H23AG antibody; MCKD1 antibody; MUC-1 antibody; ADMCKD antibody; ADMCKD1 antibody; CA15-3 antibody; MUC-1/X antibody; MUC1/ZD antibody; MUC-1/SEC antibody; EMA antibody; CD227 antibody; Muc-1 antibody; CD227 antibody; CD227 antibody; H23AG antibody; EMA antibody; MUC1 antibody; EMA antibody; PUM antibody; KL-6 antibody; MAM6 antibody; MUC-1 antibody; Muc-1 Mucin 1 antibody; Mucin 1 antibody; PEM antibody; PEMT antibody; RP11-263K19.2 antibody
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MUC1/Mucin 1/CD227 . The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
0.2 μm filtered solution in PBS
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human MUC1/Mucin 1/CD227.
Human MUC1/Mucin 1/CD227 Immunohistochemistry(IHC) 16042
Human MUC1/Mucin 1/CD227 Immunohistochemistry(IHC) 16041
Human MUC1/Mucin 1/CD227 Immunohistochemistry(IHC) 16039
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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