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Product Name
Anti-MSR1/CD204 antibody
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Description
Rabbit polyclonal to MSR1/CD204
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Tested applications
ELISA, WB
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Species reactivity
Human MSR1 / CD204
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Alternative names
MSR antibody; Scvr antibody; MRS-A antibody; MSR-A antibody; SR-AI antibody; SR-AII antibody; Scara1 antibody; SRA antibody; SR-A antibody; CD204 antibody; phSR1 antibody; phSR2 antibody; SCARA1 antibody; CD204 antibody; MRS-A antibody; MSR antibody; MSR1 antibody; Msr1 antibody; MSR-A antibody; phSR1 antibody; phSR2 antibody; Scara1 antibody; SCARA1 antibody; Scvr antibody; SR-A antibody; SR-AI antibody; SR-AII antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human MSR1 / CD204 (rh MSR1 / CD204; NP_619729.1; Lys77-Leu451). MSR1 / CD204 specific IgG was purified by Human MSR1 / CD204 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human MSR1 / CD204. The detection limit for Human MSR1 / CD204 is < 0.039 ng/well.
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Validations
MSR1 / CD204 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type I I membrane protein which contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.
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References
- Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
- Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
- Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
- Sun J. et al., 2006, Prostate. 66 (7): 728-37.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"