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Product Name
Anti-MLKL Rabbit antibody
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Description
MLKL Rabbit polyclonal antibody
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Tested applications
WB, IHC-P
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Species reactivity
Human
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthesized peptide derived from human MLKL
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Clonality
Polyclonal
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Formulation
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/500-1/2000 IHC 50-200
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Validations
Western blot analysis of MLKL expression in HUVEC cell lysate.
Immunohistochemical analysis of paraffin-embedded human colon, using MLKL Antibody.
Western blot analysis of MLKL expression in 3T3,SW480,Ramos and Hela cell lysates using MLKL antibody at 1/1000 dilution.Predicted band size:54KDa.Observed band size:54KDa.
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Background
Swiss-Prot Acc.Q8NB16.Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"