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Product Name
Anti-MESDC2 antibody
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Description
Rabbit polyclonal to MESDC2
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Tested applications
WB, IP
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Species reactivity
Human MESDC2 / MESD
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Alternative names
msd antibody; mesd antibody; AW537813 antibody; mKIAA0081 antibody; 2210015O11Rik antibody; BOCA antibody; MESD antibody; 2210015O11Rik antibody; AW537813 antibody; BOCA antibody; KIAA0081 antibody; MESD antibody; Mesdc2 antibody; MESDC2 antibody; MGC25959 antibody; mKIAA0081 antibody; UNQ1911/PRO4369 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human MESDC2 (rh MESDC2; NP_055969.1; Ala 34-Lys 230). MESDC2 specific IgG was purified by human MESDC2 affinity chromatography
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 1-5 μg/mL
IP: 1-4 μg/mg of lysate
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Validations
MESDC2 / MESD Antibody, Rabbit PAb, Antigen Affinity Purified
MESDC2 / MESD Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
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References
- Scanlan M.J. et al., 1999, Int. J. Cancer 83:456-464.
- Veltman,IM. et al.,2005, Hum Mol Genet 14 (14):1955-63.
- Koduri V. et al., 2007, Biochemistry 46:6570-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"