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Product Name
Anti-MEF2A Rabbit antibody
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Description
MEF2A Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
mef2; ADCAD1; RSRFC4; RSRFC9 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human MEF2A
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:2000-1:10000
1:20-1:50
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Validations
Western blot detection of MEF2A in K562,Rat Brain,C6,3T3,Hela cell lysates using MEF2A Rabbit mAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:55kDa.
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Background
Swiss-Prot Acc.Q02078.Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"