Anti-MCP-3/CCL7 antibody

Anti-MCP-3/CCL7 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to MCP-3/CCL7

FCM

Human MCP-3 / CCL7
Has cross-reactivity in ELISA with Human CCL1; Human CCL8
No cross-reactivity in ELISA with Human CCL11

Ccl7 antibody; MARC antibody; marc antibody; mcp3 antibody; MCP3 antibody; MCP-3 antibody; MCP-3 antibody; MGC138465 antibody; NC28 antibody; RP23-350G1.4 antibody; SCYA7 antibody; CCL7 antibody; FIC antibody; fic antibody; MGC138463 antibody; SCYA6 antibody; Scya7 antibody; FIC antibody; MARC antibody; MCP3 antibody; NC28 antibody; MCP-3 antibody; SCYA6 antibody; SCYA7 antibody; fic antibody; marc antibody; mcp3 antibody; MCP-3 antibody; Scya7 antibody

Mouse IgG1

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MCP-3 / CCL7 (rh MCP-3 / CCL7; NP_006264.2; Gln24-Leu99) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 7(CCL7), also known as MCP-3, is a isform of the C-C chemokine subfamily of the chemokine family which is produced by certain tumor cells and by macrophages. It also own two adjacent N-terminal cysteine residues. Chemokine ligand 7(CCL7) spacifically attracts monocytes, and regulates macrophage function.

• Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
• Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8⁺ T cells. Science. 270 (5243): 1811-5.
• Michalec L, et al. (2002) CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation. The Journal of Immunology. 168: 846-52.
• Wetzel K,et al. (2007) MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells.International Journal of Cancer. 120(6):1364-71.