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Product Name
Anti-MBL-2 / MBL antibody
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Description
Rabbit polyclonal to MBL-2 / MBL
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Tested applications
WB, IP
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Species reactivity
human MBL2
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Alternative names
COLEC1 antibody; HSMBPC antibody; L-MBP antibody; MBL antibody; MBL antibody; Mbl2 antibody; MBL2 antibody; MBL-C antibody; MBP antibody; MBP1 antibody; MBP-C antibody; MGC116832 antibody; MGC116833 antibody; MBL antibody; MBP antibody; MBP1 antibody; MBPD antibody; MBL2D antibody; MBP-C antibody; COLEC1 antibody; HSMBPC antibody; MBL antibody; L-MBP antibody; MBL-C antibody; MBP-C antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the C-terminus of the human MBL2, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
IP: 1-4 μg/mg of lysate
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Validations
MBL2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
MBL2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
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References
- Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
- Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
- Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
- Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
- Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"