Anti-MAPKAPK3 antibody

Anti-MAPKAPK3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human MAPKAPK3

IHC-P

Human MAPKAPK3 / MK3

3PK antibody; MK-3 antibody; MAPKAP3 antibody; MAPKAP-K3 antibody; MAPKAPK-3 antibody; 3PK antibody; MK3 antibody; MK-3 antibody; MAPKAP3 antibody; AI874665 antibody; MAPKAP-K3 antibody; MapkKapk3 antibody; 3PK antibody; 3PK antibody; AI874665 antibody; MAPKAP3 antibody; MAPKAP3 antibody; Mapkapk3 antibody; MAPKAPK3 antibody; MapkKapk3 antibody; MK3 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human MAPKAPK3 / MK3 . MAPKAPK3 / MK3 specific IgG was purified by Human MAPKAPK3 / MK3 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

The MAPKAP kinases are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is Widely expressed in human tissues, with a higher expression level observed in heart and skeletal muscle. No expression in brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines, and translocates to the cytoplasm from nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however the mechanism defining the specificity remains unknown.