Anti-MAPK12 / SAPK3 antibody

Anti-MAPK12 / SAPK3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to MAPK12 / SAPK3

ELISA, WB, IP

Human ERK3 / MAPK12 / P38-gamma

mitogen-activated protein kinase 12 antibody; MAPK12 antibody; ERK3 antibody; ERK6 antibody; P38GAMMA antibody; PRKM12 antibody; SAPK-3 antibody; SAPK3 antibody; ERK-6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; extracellular signal-regulated kinase 6 antibody; mitogen-activated protein kinase 3 antibody; mitogen-activated protein kinase p38 gamma antibody; stress-activated protein kinase 3 antibody; ERK3 antibody; mitogen-activated protein kinase 12 antibody; Mapk12 antibody; AW123708 antibody; Erk6 antibody; P38gamma antibody; Prkm12 antibody; Sapk3 antibody; ERK-6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; extracellular signal-regulated kinase 6 antibody; mitogen-activated protein kinase p38 gamma antibody; stress activated protein kinase 3 antibody; ERK6 antibody; ERK-6 antibody; SAPK3 antibody; PRKM12 antibody; SAPK-3 antibody; MAPK12 antibody; P38GAMMA antibody; Erk6 antibody; Sapk3 antibody; Prkm12 antibody; AW123708 antibody; P38gamma antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human ERK3 / MAPK12 / P38-gamma (rh ERK3 / MAPK12 / P38-gamma; P53778; Met1-Leu367). ERK3 / MAPK12 / P38-gamma specific IgG was purified by Human ERK3 / MAPK12 / P38-gamma affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

• Stiffler MA. et al., 2006, J Am Chem Soc. 128 (17): 5913-22.
• Joneson T. et al., 1997, J Mol Med. 75 (8): 587-93.
• Hou SW. et al., 2010, Cancer Res. 70 (7): 2901-10.