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Product Name
Anti-LILRA5 antibody
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Description
Rabbit polyclonal to LILRA5
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Tested applications
WB
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Species reactivity
Human LILRA5/CD85f
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Alternative names
CD85 antibody; LIR9 antibody; CD85F antibody; ILT11 antibody; LIR-9 antibody; ILT-11 antibody; LILRB7 antibody; Gm4878 antibody; Lilrc1 antibody; EG232801 antibody; E030017K20 antibody; CD85 antibody; CD85 antigen-like family member F antibody; CD85F antibody; E030017K20 antibody; EG232801 antibody; Gm4878 antibody; ILT11 antibody; ILT-11 antibody; immunoglobulin-like transcript 11 protein antibody; leukocyte Ig-like receptor 9 antibody; leukocyte immunoglobulin-like receptor antibody; leukocyte immunoglobulin-like receptor antibody; leukocyte immunoglobulin-like receptor 9 antibody; leukocyte immunoglobulin-like receptor subfamily A member 5 antibody; leukocyte immunoglobulin-like receptor subfamily A member 5 soluble antibody; LILRB7 antibody; Lilrc1 antibody; LIR9 antibody; LIR-9 antibody; member 7 antibody; subfamily B (with TM and ITIM domains) antibody; XXbac-BCX403H19.2 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human LILRA5/CD85f, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-30 μg/ml
IHC-P: 0.1-2 μg/mL
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Validations
LILRA5 / CD85f Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
LILRA5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LILR are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells. ILT-11 contains 2 Ig-like C2-type (immunoglobulin-like) domains. It can be detected n tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.
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References
- Wende H, et al. (2000) Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Immunogenetics. 51(8-9):703-13.
- Jones DC, et al. (2009) Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. Eur J Immunol. 39(11):3195-206.
- Mosbruger TL, et al. (2010) Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 201(9):1371-80.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"