Anti-Lck (2E5) Mouse antibody

Cat.#: 168388

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Product Information

  • Product Name
    Anti-Lck (2E5) Mouse antibody
  • Documents
  • Description
    Lck (2E5) Mouse monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human
  • Isotype
    Mouse IgG2a
  • Preparation
    Antigen: Purified recombinant fragment of human Lck expressed in E. Coli.
  • Clonality
    Monoclonal
  • Formulation
    Ascitic fluid containing 0.03% sodium azide.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500 - 1/2000

    ELISA: 1/10000

  • Validations

    Western blot detection of Lck in Jurkat and Ramos cell lysates and using Lck mouse mAb (1:1000 diluted).Predicted band size: 56KDa.Observed band size: 56KDa.

    Western blot detection of Lck in Jurkat and Ramos cell lysates and using Lck mouse mAb (1:1000 diluted).Predicted band size: 56KDa.Observed band size: 56KDa.

  • Background
    Swiss-Prot Acc.P06239.Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"