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Product Name
Anti-LAMP2/CD107b antibody
- Documents
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Description
Rabbit polyclonal to LAMP2/CD107b
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Tested applications
ELISA, WB
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Species reactivity
Mouse LAMP2 / CD107b
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Alternative names
LAMPB antibody; CD107b antibody; LAMP-2 antibody; LGP110 antibody; Mac3 antibody; LGP-B antibody; CD107b antibody; Lamp-2 antibody; LampII antibody; Lamp-2a antibody; Lamp-2b antibody; Lamp-2c antibody; CD107b antibody; CD107b antibody; LAMP2 antibody; Lamp-2 antibody; Lamp-2a antibody; Lamp-2b antibody; Lamp-2c antibody; LAMPB antibody; Mac3 antibody; LAMP2 antibody; LGP110 antibody; RP23-193O17.2 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse LAMP2 / CD107b (rh LAMP2 / CD107b; P17047-1; Leu26-Asn379). LAMP2 / CD107b specific IgG was purified by Mouse LAMP2 / CD107b affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LAMP2 / CD107b. The detection limit for Mouse LAMP2 / CD107b is < 0.039 ng/well.
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Validations
LAMP2 / CD107b Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
LAMP2 (Lysosomal-associated membrane protein 2), also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.
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References
- Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.
- Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.
- Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"