Anti-L1CAM antibody

Anti-L1CAM antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse L1CAM

IHC-P

Mouse CD171/L1CAM

S10 antibody; HSAS antibody; MASA antibody; MIC5 antibody; SPG1 antibody; CAML1 antibody; CD171 antibody; HSAS1 antibody; N-CAML1 antibody; NCAM-L1 antibody; N-CAM-L1 antibody; L1 antibody; CD171 antibody; NCAM-L1 antibody; N-CAM-L1 antibody; CAML1 antibody; CD171 antibody; HSAS antibody; HSAS1 antibody; L1CAM antibody; MASA antibody; MIC5 antibody; N-CAML1 antibody; NCAM-L1 antibody; S10 antibody; SPG1 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Mouse CD171/L1CAM, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.