-
Product Name
Anti-KLK6/Kallikrein 6/Neurosin antibody
- Documents
-
Description
Rabbit polyclonal to KLK6/Kallikrein 6/Neurosin
-
Tested applications
ELISA, WB
-
Species reactivity
Mouse KLK6 / Kallikrein 6 / Neurosin
-
Alternative names
brain serine protease antibody; Bssp antibody; Bssp antibody; hK6 antibody; kallikrein 29 antibody; kallikrein 6 antibody; kallikrein-6 antibody; Klk29 antibody; Klk7 antibody; MSP antibody; myelencephalon-specific protease antibody; myofibril-bound protease antibody; neurosin antibody; neurosin antibody; protease antibody; protease M antibody; protease M antibody; Prss18 antibody; PRSS18 antibody; PRSS9 antibody; Prss9 antibody; serine antibody; serine protease 18 antibody; serine protease 9 antibody; SP59 antibody; zyme antibody; hK6 antibody; Bssp antibody; Klk7 antibody; SP59 antibody; PRSS9 antibody; PRSS18 antibody; BSP antibody; MSP antibody; Bssp antibody; Klk29 antibody; Prss9 antibody; Prss18 antibody; AI849898 antibody; neurosin antibody
-
Isotype
Rabbit IgG
-
Preparation
Produced in rabbits immunized with purified, recombinant Mouse KLK6 / Kallikrein 6 / Neurosin (NP_035307.2; Met 8-Leu 253). KLK6 / Kallikrein 6 / Neurosin specific IgG was purified by Mouse KLK6 / Kallikrein 6 / Neurosin affinity chromatography.
-
Clonality
Polyclonal
-
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse KLK6 / Kallikrein 6 / Neurosin. The detection limit for Mouse KLK6 / Kallikrein 6 / Neurosin is < 0.039 ng/well.
-
Validations
KLK6 / Kallikrein 6 / Neurosin Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
-
Background
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
-
References
- Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
- Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
- Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
- Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"