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Product Name
Anti-KIM-1/TIM1/HACVR1 antibody
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Description
Rabbit monoclonal to KIM-1/TIM1/HACVR1
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Tested applications
ELISA, IHC-P
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Species reactivity
Canine KIM-1 / TIMD-1 / HAVCR1
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Alternative names
TIM antibody; KIM1 antibody; TIM1 antibody; HAVCR antibody; KIM-1 antibody; TIM-1 antibody; TIMD1 antibody; TIMD-1 antibody; HAVCR-1 antibody; Tim1 antibody; KIM-1 antibody; TIM-1 antibody; Timd1 antibody; AI503787 antibody; TIMD-1 antibody; TIMD-1 antibody; AI503787 antibody; Canis lupus familiaris antibody; HAVCR antibody; HAVCR1 antibody; HAVCR1 antibody; Havcr1 antibody; Havcr1 antibody; HAVcr-1 antibody; HAVcr-1 antibody; HAVCR-1 antibody; Kim1 antibody; KIM1 antibody; KIM-1 antibody; KIM-1 antibody; RP23-31K14.2 antibody; TIM antibody; TIM1 antibody; Tim1 antibody; TIM-1 antibody; TIM-1 antibody; Timd1 antibody; TIMD1 antibody; TIMD-1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Canine HAVCR1 extracellular domain (rCanine TIMD-1 / HAVCR1; XP_854888.1; Tyr 21-Ser 160).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Canine TIMD1. The detection limit for Canine TIMD1 is approximately 0.00975 ng/well.
IHC-P: 0.5-2 μg/mL
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Validations
KIM-1 / TIMD-1 / HAVCR1 Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of Canine KIM1 in canine kidney with rabbit monoclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
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References
- Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
- Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
- Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"