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Product Name
Anti-KCTD21 Rabbit antibody
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Description
KCTD21 Rabbit polyclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
KCASH2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human KCTD21
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
FC: 1/50
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Validations
Western blot detection of KCTD21 in K562 cell lysates using KCTD21 Rabbit pAb(1:1000 diluted).Predicted band size:30kDa.Observed band size:30kDa.
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Background
Swiss-Prot Acc.Q4G0X4.Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"