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  • Anti-Kappa Opioid Receptor Rabbit antibody

Anti-Kappa Opioid Receptor Rabbit antibody

Cat.#: 168944

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Kappa Opioid Receptor Rabbit antibody
  • Documents
  • Description
    Kappa Opioid Receptor Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, IP
  • Species reactivity
    Mouse, Rat
  • Alternative names
    KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of mouse Kappa Opioid Receptor
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:1000

    1:20

    1:20

  • Validations

    Western blot detection of Kappa Opioid Receptor in Rat Brain lysates using Kappa Opioid Receptor Rabbit mAb(1:1000 diluted).Predicted band size:43kDa.Observed band size:60kDa.

    Western blot detection of Kappa Opioid Receptor in Rat Brain lysates using Kappa Opioid Receptor Rabbit mAb(1:1000 diluted).Predicted band size:43kDa.Observed band size:60kDa.

  • Background
    Swiss-Prot Acc.P33534.G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"