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Product Name
Anti-interleukin-20 antibody
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Description
Rabbit polyclonal to interleukin-20
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Tested applications
WB, IP
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Species reactivity
mouse IL20
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Alternative names
cytokine Zcyto10 antibody; cytokine Zcyto10 antibody; four alpha helix cytokine antibody; four alpha helix cytokine ZCYTO10 antibody; four helix bundle cytokine 10 antibody; IL10D antibody; IL-20 antibody; IL-20 antibody; interleukin-20 antibody; interleukin-20 antibody; MGC130536 antibody; MGC96907 antibody; UNQ852/PRO1801 antibody; ZCYTO10 antibody; IL-20 antibody; Zcyto10 antibody; IL10D antibody; ZCYTO10 antibody; Zcyto10 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the mouse mIL20 , and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-50 μg/ml
IP: 4-6 μg/mg of lysate
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Background
IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells.It has been shown that interleukin-20 transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
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References
- Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30.
- Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18.
- Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"