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  • Anti-ILF3/NF90 Rabbit antibody

Anti-ILF3/NF90 Rabbit antibody

Cat.#: 168986

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Product Information

  • Product Name
    Anti-ILF3/NF90 Rabbit antibody
  • Documents
  • Description
    ILF3/NF90 Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse
  • Alternative names
    CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; TCP110; MPHOSPH4; NF-AT-90 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human ILF3
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/2000-1/20000

    IHC: 1/50

    ICC/IF: 1/100

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of ILF3/NF90 in Jurkat,C6,Hela cell lysates using ILF3/NF90 Rabbit mAb(1:1000 diluted).Predicted band size:95kDa.Observed band size:95kDa.

    Western blot detection of ILF3/NF90 in Jurkat,C6,Hela cell lysates using ILF3/NF90 Rabbit mAb(1:1000 diluted).Predicted band size:95kDa.Observed band size:95kDa.

  • Background
    Swiss-Prot Acc.Q12906.RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"