Anti-IL36RN antibody

Anti-IL36RN antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse IL36RN

ELISA, IHC-P

Mouse IL-1F5

IL36RN antibody; RP23-176J12.6 antibody; IL1RP3 antibody; IL-1RP3 antibody; FIL1 antibody; AI413231 antibody; FIL1 delta antibody; FIL1(DELTA) antibody; FIL1D antibody; Fil1delta antibody; IL-1 delta antibody; IL-1 delta antibody; IL1F5 antibody; Il1f5 antibody; IL-1F5 antibody; IL-1F5 antibody; Il-1h3 antibody; IL1HY1 antibody; Il1hy1 antibody; IL-1HY1 antibody; IL-1HY1 antibody; IL1L1 antibody; IL-1L1 antibody; IL-1L1RP23-176J12.6 antibody; MGC29840 antibody; UNQ1896/PRO4342 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse IL-1F5 . IL-1F5 specific IgG was purified by Mouse IL-1F5 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR−/− mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain.