Anti-IL20RA/IL-20RA antibody

Anti-IL20RA/IL-20RA antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to IL20RA/IL-20RA

ELISA, IHC-P

Human IL20RA / IL-20RA
No cross-reactivity in ELISA with Human IFNgR1; Human IL10RB

E230031K19 antibody; FLJ40993 antibody; IL-20R1 antibody; Il20ra antibody; IL20RA antibody; RP11-204P2.1 antibody; ZCYTOR7 antibody; CRF2-8 antibody; IL-20R1 antibody; IL-20RA antibody; IL-20R-alpha antibody; E230031K19 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA / IL-20RA (rh IL20RA / IL-20RA; NP_055247.21; Met 1-Lys 250).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

• Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
• Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
• Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.