Anti-IL18RAP antibody

Anti-IL18RAP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human IL18RAP

WB, ELISA

Human IL18RAP

ACPL antibody; CD218 antigen-like family member B antibody; CD218b antibody; CDw218b antibody; IL-18 receptor accessory protein antibody; IL-18RAcP antibody; IL18RB antibody; IL-18R-beta antibody; MGC120589 antibody; AcPL accessory protein-like antibody; ACPL antibody; CD218b antibody; IL-1R7 antibody; IL18RB antibody; CDw218b antibody; IL-1R-7 antibody; IL-18RAcP antibody; IL-1RAcPL antibody; IL-18Rbeta antibody; IL-18R-beta antibody; AcPL antibody; IL-18RAcP antibody; IL-1RAcPL antibody; IL-18Rbeta antibody; IL-18R-beta antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human IL18RAP . IL18RAP specific IgG was purified by Human IL18RAP affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.