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Product Name
Anti-IKB beta Rabbit antibody
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Description
IKB beta Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP
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Species reactivity
Human
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Alternative names
IKBB; TRIP9 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human IKB beta
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/50
ICC/IF: 1/50
IP: 1/20
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Validations
Western blot detection of IKB beta in K562,3T3,Hela cell lysates using IKB beta Rabbit pAb(1:1000 diluted).Predicted band size:38kDa.Observed band size:48kDa.
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Background
Swiss-Prot Acc.Q15653.Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"