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Product Name
Anti-IHPK1 antibody
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Description
Rabbit polyclonal to IHPK1
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Tested applications
ELISA, WB
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Species reactivity
Human IHPK1
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Alternative names
1200016D08Rik antibody; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase antibody; AU022776 antibody; IHPK1 antibody; Ihpk1 antibody; inositol hexakisphosphate kinase 1 antibody; inositol hexakisphosphate kinase 6 antibody; inositol hexaphosphate kinase 1 antibody; InsP6 antibody; insP6 kinase 1 antibody; insP6 kinase 1 antibody; Itpk6 antibody; Pi uptake stimulator antibody; PiUS antibody; Ihpk1 antibody; InsP6 antibody; Itpk6 antibody; InsP6k1 antibody; AU022776 antibody; 1200016D08Rik antibody; PiUS antibody; IHPK1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human IHPK1 (rh IHPK1; Q92551-1; Met1-Gln441). IHPK1 specific IgG was purified by Human IHPK1 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IHPK1. The detection limit for Human IHPK1 is < 0.039 ng/well.
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Validations
IHPK1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
IHPK1 is a inositol hexaphosphate kinase (IHPK) protein which belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family.
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References
- Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
- Saiardi A, et al. (2001) Identification and characterization of a novel inositol hexakisphosphate kinase. J Biol Chem. 276(42):39179-85.
- Kamimura J, et al. (2004) The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. J Hum Genet. 49(7):360-5.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"