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Product Name
Anti-HRH3/Histamine 3 Receptor Rabbit antibody
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Description
HRH3/Histamine 3 Receptor Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
HH3R; GPCR97 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human HRH3/Histamine 3 Receptor
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
ICC/IF: 1/50
FC: 1/20-1/100
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Validations
Western blot detection of HRH3/Histamine 3 Receptor in K562,C6,3T3 cell lysates using HRH3/Histamine 3 Receptor Rabbit pAb(1:1000 diluted).Predicted band size:49kDa.Observed band size:49kDa.
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Background
Swiss-Prot Acc.Q9Y5N1.The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.MiscellaneousDoes not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R--alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"