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  • Anti-HMG4 Rabbit antibody

Anti-HMG4 Rabbit antibody

Cat.#: 169039

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-HMG4 Rabbit antibody
  • Documents
  • Description
    HMG4 Rabbit monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    HMG4; HMG-4; HMG2A; HMG-2a antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human HMG4
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    1:2000-1:10000

  • Validations

    Western blot detection of HMG4 in K562,C6,3T3,Hela cell lysates using HMG4 Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:23kDa.

    Western blot detection of HMG4 in K562,C6,3T3,Hela cell lysates using HMG4 Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:23kDa.

  • Background
    Swiss-Prot Acc.O15347.Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"