Anti-HMG4 Rabbit antibody
HMG4 Rabbit monoclonal antibody
Human, Mouse, Rat
HMG4; HMG-4; HMG2A; HMG-2a antibody
Antigen: A synthetic peptide of human HMG4
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of HMG4 in K562,C6,3T3,Hela cell lysates using HMG4 Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:23kDa.
Swiss-Prot Acc.O15347.Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"